Freudenthal, Bret D : rechercher sur Z-Library

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1

Observing a DNA Polymerase Choose Right from Wrong

Freudenthal, Bret D., Beard, William A., Shock, David D., Wilson, Samuel H.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 4.10 MB

english, 2013

2

Variations on a theme: Eukaryotic Y-family DNA polymerases

M. Todd Washington, Karissa D. Carlson, Bret D. Freudenthal, John M. Pryor

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2010

Langue:

english

Fichier:

PDF, 975 KB

english, 2010

3

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange

Freudenthal, Bret D, Gakhar, Lokesh, Ramaswamy, S, Washington, M Todd

Journal:

Nature Structural and Molecular Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2010

4

Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

Bret D. Freudenthal, John E. Brogie, Lokesh Gakhar, Christine M. Kondratick, M. Todd Washington

Journal:

Journal of Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2011

5

Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly

Bret D. Freudenthal, William A. Beard, Samuel H. Wilson

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2012

6

Optimal and Variant Metal-Ion Routes in DNA Polymerase β’s Conformational Pathways

Li, Yunlang, Freudenthal, Bret D., Beard, William A., Wilson, Samuel H., Schlick, Tamar

Journal:

Journal of the American Chemical Society

Année:

2014

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2014

7

Structurally Distinct Complexes of Ubiquitin and Sumo-Modified PCNA Lead to Distinct DNA Damage Response Pathways

Tsutakawa, Susan, Yan, Chunli, Xu, Xiaojun, Freudenthal, Bret, Weinacht, Christopher, Zhuang, Zhihao, Washington, Todd, Ivanov, Ivaylo

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 104 KB

english, 2014

8

Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis †‡

Freudenthal, Bret D., Ramaswamy, S., Hingorani, Manju M., Washington, M. Todd

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 3.61 MB

english, 2008

9

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Freudenthal, Bret D., Beard, William A., Perera, Lalith, Shock, David D., Kim, Taejin, Schlick, Tamar, Wilson, Samuel H.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 8.36 MB

english, 2014

10

New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis

Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2015

11

Structurally Distinct Ubiquitin- and Sumo-Modified PCNA: Implications for Their Distinct Roles in the DNA Damage Response

Tsutakawa, Susan E., Yan, Chunli, Xu, Xiaojun, Weinacht, Christopher P., Freudenthal, Bret D., Yang, Kun, Zhuang, Zhihao, Washington, M. Todd, Tainer, John A., Ivanov, Ivaylo

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 2.97 MB

english, 2015

12

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

Fedeles, Bogdan I., Freudenthal, Bret D., Yau, Emily, Singh, Vipender, Chang, Shiou-chi, Li, Deyu, Delaney, James C., Wilson, Samuel H., Essigmann, John M.

Journal:

Proceedings of the National Academy of Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2015

13

Watching a DNA polymerase in action

Freudenthal, Bret D, Beard, William A, Wilson, Samuel H

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 422 KB

english, 2014

14

Capturing snapshots of APE1 processing DNA damage

Freudenthal, Bret D, Beard, William A, Cuneo, Matthew J, Dyrkheeva, Nadezhda S, Wilson, Samuel H

Journal:

Nature Structural and Molecular Biology

Année:

2015

Fichier:

PDF, 3.73 MB

2015

15

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

Perera, Lalith, Freudenthal, Bret D., Beard, William A., Shock, David D., Pedersen, Lee G., Wilson, Samuel H.

Journal:

Proceedings of the National Academy of Sciences

Année:

2015

Fichier:

PDF, 1.45 MB

2015

16

Capturing snapshots of APE1 processing DNA damage

Freudenthal, Bret D, Beard, William A, Cuneo, Matthew J, Dyrkheeva, Nadezhda S, Wilson, Samuel H

Journal:

Nature Structural and Molecular Biology

Année:

2015

Langue:

english

Fichier:

PDF, 3.73 MB

english, 2015

17

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse

Perera, Lalith, Freudenthal, Bret D., Beard, William A., Shock, David D., Pedersen, Lee G., Wilson, Samuel H.

Journal:

Proceedings of the National Academy of Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2015

18

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

Susan E. Tsutakawa, Adam W. Van Wynsberghe, Bret D. Freudenthal, Christopher P. Weinacht, Lokesh Gakhar, M. Todd Washington, Zhihao Zhuang, John A. Tainer and Ivaylo Ivanov

Journal:

Proceedings of the National Academy of Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2011

19

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening

Kim, Taejin, Freudenthal, Bret D., Beard, William A., Wilson, Samuel H., Schlick, Tamar

Journal:

Nucleic Acids Research

Année:

2016

Langue:

english

Fichier:

PDF, 12.00 MB

english, 2016

20

Oxidative guanine base damage regulates human telomerase activity

Fouquerel, Elise, Lormand, Justin, Bose, Arindam, Lee, Hui-Ting, Kim, Grace S, Li, Jianfeng, Sobol, Robert W, Freudenthal, Bret D, Myong, Sua, Opresko, Patricia L

Journal:

Nature Structural and Molecular Biology

Année:

2016

Langue:

english

Fichier:

PDF, 2.84 MB

english, 2016

21

Capturing a mammalian DNA polymerase extending from an oxidized nucleotide

Whitaker, Amy M., Smith, Mallory R., Schaich, Matthew A., Freudenthal, Bret D.

Journal:

Nucleic Acids Research

Année:

2017

Langue:

english

Fichier:

PDF, 4.03 MB

english, 2017

22

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

Shock, David D, Freudenthal, Bret D, Beard, William A, Wilson, Samuel H

Journal:

Nature Chemical Biology

Année:

2017

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2017

23

Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues

Schaich, Matthew A., Smith, Mallory R., Cloud, Ashley S., Holloran, Sean M., Freudenthal, Bret D.

Journal:

Chemical Research in Toxicology

Année:

2017

Langue:

english

Fichier:

PDF, 3.36 MB

english, 2017

24

Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

Whitaker, Amy M., Flynn, Tony S., Freudenthal, Bret D.

Journal:

Nature Communications

Année:

2018

Langue:

english

Fichier:

PDF, 2.71 MB

english, 2018

25

Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Bastola, Prabhakar, Wang, Feng, Schaich, Matthew A, Gan, Taiping, Freudenthal, Bret D, Chou, Tsui-Fen, Chien, Jeremy

Journal:

Cell Death Discovery

Année:

2017

Langue:

english

Fichier:

PDF, 2.84 MB

english, 2017

26

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

Liu, Lili, Kong, Muwen, Gassman, Natalie R., Freudenthal, Bret D., Prasad, Rajendra, Zhen, Stephanie, Watkins, Simon C., Wilson, Samuel H., Van Houten, Bennett

Journal:

Nucleic Acids Research

Année:

2017

Langue:

english

Fichier:

PDF, 4.23 MB

english, 2017

27

Base excision repair of oxidative DNA damage from mechanism to disease

Freudenthal, Bret D

Journal:

Frontiers in Bioscience

Année:

2017

Langue:

english

Fichier:

PDF, 5.34 MB

english, 2017

28

Revealing the role of the product metal in DNA polymerase β catalysis

Perera, Lalith, Freudenthal, Bret D., Beard, William A., Pedersen, Lee G., Wilson, Samuel H.

Journal:

Nucleic Acids Research

Année:

2017

Langue:

english

Fichier:

PDF, 4.39 MB

english, 2017

29

APE1: A skilled nucleic acid surgeon

Whitaker, Amy M., Freudenthal, Bret D.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2018

30

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition

Smith, Mallory R, Shock, David D, Beard, William A, Greenberg, Marc M, Freudenthal, Bret D, Wilson, Samuel H

Journal:

Nucleic Acids Research

Année:

2019

Langue:

english

Fichier:

PDF, 5.43 MB

english, 2019

31

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

Akakpo, Jephte Y, Ramachandran, Anup, Duan, Luqi, Schaich, Matthew A, Jaeschke, Matthew W, Freudenthal, Bret D, Ding, Wen-Xing, Rumack, Barry H, Jaeschke, Hartmut

Journal:

Toxicological Sciences

Année:

2019

Fichier:

PDF, 2.56 MB

2019

32

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

Akakpo, Jephte Y, Ramachandran, Anup, Duan, Luqi, Schaich, Matthew A, Jaeschke, Matthew W, Freudenthal, Bret D, Ding, Wen-Xing, Rumack, Barry H, Jaeschke, Hartmut

Journal:

Toxicological Sciences

Année:

2019

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2019

33

Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance

McNeill, Daniel R, Whitaker, Amy M, Stark, Wesley J, Illuzzi, Jennifer L, McKinnon, Peter J, Freudenthal, Bret D, Wilson, David M

Journal:

Année:

2019

Fichier:

PDF, 737 KB

2019

34

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase Î²

Smith, Mallory R., Alnajjar, Khadijeh S., Hoitsma, Nicole M., Sweasy, Joann B., Freudenthal, Bret D.

Journal:

Journal of Biological Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 2.15 MB

english, 2020

35

Molecular and structural characterization of disease-associated APE1 polymorphisms

Whitaker, Amy M., Stark, Wesley J., Flynn, Tony S., Freudenthal, Bret D.

Journal:

Année:

2020

Fichier:

PDF, 2.56 MB

2020

36

AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop

Hoitsma, Nicole M, Whitaker, Amy M, Beckwitt, Emily C, Jang, Sunbok, Agarwal, PratulÂ K, VanÂ Houten, Bennett, Freudenthal, Bret D

Journal:

Nucleic Acids Research

Année:

2020

Fichier:

PDF, 3.01 MB

2020

37

Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5â² mismatches

Fairlamb, Max S., Whitaker, Amy M., Freudenthal, Bret D.

Journal:

Acta Crystallographica Section D Structural Biology

Année:

2018

Fichier:

PDF, 1.18 MB

2018

38

Visualizing Rev1 catalyze protein-template DNA synthesis

Weaver, Tyler M., Cortez, Luis M., Khoang, Thu H., Washington, M. Todd, Agarwal, Pratul K., Freudenthal, Bret D.

Journal:

Proceedings of the National Academy of Sciences

Année:

2020

Fichier:

PDF, 1.98 MB

2020

39

Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

Sanford, Samantha L., Welfer, Griffin A., Freudenthal, Bret D., Opresko, Patricia L.

Journal:

Nature Communications

Année:

2020

Fichier:

PDF, 2.64 MB

2020